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Aequorin
Aequorin, isolated from the jellyfish Aequorea victoria, is a complex of the luciferin derivative coelenterazine, molecular oxygen and the apoprotein. If activated by Ca2+ binding it catalyses the oxidation of coelenterazine to the excited state coelenteramide. When coelenteramide returns to its ground state, blue light at 470 nm is emitted. In light microscopy aequorin has proven useful as an ion sensing dye, permitting the visualisation and measurement of intracellular Ca2+ fluctuations.
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